What question did this study set out to answer?

To evaluate the broad-spectrum antibacterial activity and sustained delivery potential of biofabricated gold nanoparticle-antibiotic conjugates against clinical coagulase-negative staphylococci.

July 14, 2015Gold bulletinOpen Access

Effect of biofabricated gold nanoparticle-based antibiotic conjugates on minimum inhibitory concentration of bacterial isolates of clinical origin

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Authors

RTRoshmi ThomasMahatma Gandhi University KSK. R. SoumyaKrishi Vigyan Kendra, Latur JMJyothis MathewMahatma Gandhi University

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Implication

In vitro study demonstrates enhanced efficacy of biofabricated gold nanoparticle-antibiotic conjugates against clinical staphylococci, highlighting their utility for coating medical devices.

Key Points

To evaluate the broad-spectrum antibacterial activity and sustained delivery potential of biofabricated gold nanoparticle-antibiotic conjugates against clinical coagulase-negative staphylococci.
Biosynthesized stable gold nanoparticles using a Bacillus species.
Functionalized the gold nanoparticles with four standard antibiotics: ciprofloxacin, gentamycin, rifampicin, and vancomycin.
Tested the antibacterial efficiency of the conjugates against clinical isolates of Staphylococcus epidermidis and Staphylococcus haemolyticus in comparison to free antibiotics and unconjugated nanoparticles.
Gold nanoparticle-antibiotic conjugates exhibited substantially higher antibacterial efficiency against both clinical Staphylococcus epidermidis and Staphylococcus haemolyticus compared to pure antibiotics alone.
Pure gold nanoparticles showed lower activity on their own, demonstrating synergistic antibacterial enhancement upon antibiotic conjugation.

Cite This Study

Thomas et al. (2015) studied this question.

synapsesocial.com/papers/6a768cb5dc95071596cfef2f https://doi.org/10.1007/s13404-015-0162-4

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Implication

In vitro study demonstrates enhanced efficacy of biofabricated gold nanoparticle-antibiotic conjugates against clinical staphylococci, highlighting their utility for coating medical devices.

Effect of biofabricated gold nanoparticle-based antibiotic conjugates on minimum inhibitory concentration of bacterial isolates of clinical origin

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of biofabricated gold nanoparticle-based antibiotic conjugates on minimum inhibitory concentration of bacterial isolates of clinical origin

Discussion

Member takes

Implication

Key Points

Cite This Study

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