What question did this study set out to answer?

To evaluate the expression of the checkpoint molecule programmed death ligand 1 (PD-L1) in the blood of patients with active tuberculosis compared to healthy and exposed controls.

April 20, 2011European Journal of ImmunologyOpen Access

Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis

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Authors

FMFinlay W. McNabAge UK MBMatthew BerryUniversity of Illinois Urbana-Champaign CGChristine M. GrahamThe Francis Crick Institute

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Implication

Comparative analysis demonstrates elevated neutrophil PD-L1 expression in active tuberculosis, suggesting a mechanism of immune suppression during infection.

Key Points

To evaluate the expression of the checkpoint molecule programmed death ligand 1 (PD-L1) in the blood of patients with active tuberculosis compared to healthy and exposed controls.
Assessed PD-L1 expression in whole blood samples from patients with active tuberculosis, healthy controls, and individuals exposed to Mycobacterium tuberculosis.
Identified the specific cellular subsets responsible for altered PD-L1 expression in circulation.
Expression of PD-L1 was elevated in the whole blood of active tuberculosis patients relative to healthy controls and Mycobacterium tuberculosis-exposed individuals.
Circulating neutrophils were identified as the primary cell type driving the observed increase in PD-L1 expression.

Cite This Study

McNab et al. (2011) studied this question.

synapsesocial.com/papers/6a768cdb98f24dbf64bd3af4 https://doi.org/10.1002/eji.201141421

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Implication

Comparative analysis demonstrates elevated neutrophil PD-L1 expression in active tuberculosis, suggesting a mechanism of immune suppression during infection.

Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Programmed death ligand 1 is over‐expressed by neutrophils in the blood of patients with active tuberculosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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