Why the study?
Although reduced ejection fraction in Duchenne muscular dystrophy typically manifests in the second decade, subtle alterations in LV mechanics can be detected earlier using speckle tracking echocardiography.
Does speckle tracking echocardiography detect early myocardial strain impairment in children with Duchenne muscular dystrophy compared to healthy controls?
Population
32 DMD children with preserved LV function and 24 age-matched healthy subjects
Comparison
DMD children divided by age (younger vs older than 9 years) vs healthy controls
Design
Retrospective study
Authors
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Speckle tracking may detect early LV dysfunction in DMD children; leaves open whether it guides therapy or improves outcomes.
Does speckle tracking echocardiography detect early myocardial strain impairment in children with Duchenne muscular dystrophy compared to healthy controls?
Speckle tracking echocardiography detects early subclinical left ventricular dysfunction in children with Duchenne muscular dystrophy despite preserved ejection fraction.
Oreto et al. (2020) studied this question.
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