Why the study?
Does Major Depressive Disorder alter time domain measures of Heart Rate Variability compared to healthy controls?
Population
90 subjects aged 20-50 years, comprising 60 patients of both sexes with Major Depressive Disorder and 30…
Comparison
Major Depressive Disorder, either drug-naïve or… vs Age, sex, and BMI-matched apparently healthy…
Design
Cross-sectional
Authors
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HRV time-domain measures may signal autonomic imbalance in MDD; hypothesis-generating and requires prospective validation before any clinical use.
Does Major Depressive Disorder alter time domain measures of Heart Rate Variability compared to healthy controls?
Major Depressive Disorder is associated with impaired cardiac autonomic nerve function characterized by reduced vagal tone, which does not appear to be modified by antidepressant medication.
Jahan et al. (2016) studied this question.
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