Why the study?
Do patients with major depression have altered autonomic nervous system function compared to healthy controls?
Population
36 subjects: 18 patients with major depression and 18 healthy control subjects.
Comparison
Cardiovascular tests of autonomic function and… vs Healthy control subjects.
Design
Case-control
Authors
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Supports autonomic imbalance in major depression; leaves open causal CV links and need for prospective confirmation before practice change.
Do patients with major depression have altered autonomic nervous system function compared to healthy controls?
Major depression is associated with diminished parasympathetic reactivity and increased sympathetic reactivity, as assessed by cardiovascular autonomic tests and sympathetic skin responses.
Guinjoan et al. (1995) studied this question.
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