November 2, 1995European Heart Journal
Role of the fibrinolytic system in preventing myocardial infarction
Why the study?
Does pharmacological interruption of the renin-angiotensin system with ACE inhibitors improve endogenous fibrinolytic balance and prevent acute myocardial infarction?
Design
Review
Authors
Discussion
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Member takes
Implication
Supports RAS blockade improving fibrinolysis; leaves open prospective trials to confirm MI prevention benefit.
Structured PICO
Does pharmacological interruption of the renin-angiotensin system with ACE inhibitors improve endogenous fibrinolytic balance and prevent acute myocardial infarction?
I
Intervention
Pharmacological interruption of the renin-angiotensin system (ACE inhibitors)
O
Outcome
Prevention of acute myocardial infarction
The review highlights that ACE inhibitors may prevent acute myocardial infarction partly by improving the endogenous fibrinolytic balance through interruption of the renin-angiotensin system.
Cite This Study
Vaughan et al. (1995) studied this question.