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August 14, 2014The Anatomical RecordOpen Access

Probing Muscle Ankyrin‐Repeat Protein (MARP) Structure and Function

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Authors

ALAlexander Shiang LunUniversity of California, San Diego JCJu ChenMacau University of Science and Technology SLStephan LangeGeneral Cardiology

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Implication

Structural insights into MARP dimerization and titin binding extend mechanistic models; leaves open therapeutic targeting in myopathies.

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Cite This Study

Lun et al. (2014) studied this question.

synapsesocial.com/papers/6a76a827d8eb58afc2bd5147 https://doi.org/10.1002/ar.22968

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway1997 · 276 citations
2Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease2011 · 80 citations
3Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy2009 · 76 citations
4A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics2012 · 99 citations
5Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H2O22011 · 52 citations