Why the study?
Does calcium affect passive myocardial tension in a titin isoform-dependent manner?
Population
Skinned myocardium expressing either predominantly N2B titin or predominantly N2BA titin
Comparison
Calcium exposure during and after stretch vs Absence of calcium
Design
Preclinical
Authors
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Calcium may modulate passive stiffness isoform-dependently in animal myocardium; leaves open translation to human diastolic function or therapy.
Does calcium affect passive myocardial tension in a titin isoform-dependent manner?
Calcium affects passive myocardial tension in a titin isoform-dependent manner, requiring E-rich PEVK motifs present in N2BA but absent in N2B titin.
Fujita et al. (2004) studied this question.
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