January 20, 2007Journal of Biological ChemistryOpen Access

Conformation-dependent Stability of Junctophilin 1 (JP1) and Ryanodine Receptor Type 1 (RyR1) Channel Complex Is Mediated by Their Hyper-reactive Thiols

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Population

Skeletal muscle proteins Junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1)

Design

Preclinical

Authors

APAndrew PhimisterGenomics Institute of the Novartis Research Foundation JLJózsef LangóUC Davis Comprehensive Cancer Center ELEun Hui LeeCatholic University of Korea

Discussion

Member takes

Implication

Does not support clinical translation; leaves open JP1-RyR1 redox sensing as a hypothesis-generating target in muscle.

Structured PICO

Population

Skeletal muscle proteins Junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1)

Intervention

Conditions modulating RyR1 gating (e.g., 10 mM Mg2+ vs 100 microM Ca2+, 10 mM caffeine, 5 mM ATP) and oxidation

Outcome

Thiol labeling rate and physical interaction between JP1 and RyR1surrogate

JP1 interacts with the RyR1 channel complex in a conformationally sensitive manner, potentially contributing redox-sensing properties through reactive sulfhydryl chemistry.

Cite This Study

Phimister et al. (2007) studied this question.

synapsesocial.com/papers/6a76a8fb2ea07b97ffadf3eb https://doi.org/10.1074/jbc.m609936200

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Conformation-dependent Stability of Junctophilin 1 (JP1) and Ryanodine Receptor Type 1 (RyR1) Channel Complex Is Mediated by Their Hyper-reactive Thiols

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Conformation-dependent Stability of Junctophilin 1 (JP1) and Ryanodine Receptor Type 1 (RyR1) Channel Complex Is Mediated by Their Hyper-reactive Thiols

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider