October 22, 2011Journal of Biological ChemistryOpen Access

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+ Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

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Population

C2C12 cells (skeletal muscle model)

Comparison

Knockdown of JP1 and JP2 vs Control cells

Design

Preclinical

Authors

LGLucia GoliniUniversity of Siena CCChristophe ChouabeUniversité Claude Bernard Lyon 1 CBChristine BerthierUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Supports JP-DHPR interaction in skeletal muscle EC coupling in vitro; leaves open in vivo relevance to myopathies or cardiac disease.

Structured PICO

Population

C2C12 cells (skeletal muscle model)

Intervention

Knockdown of JP1 and JP2

Comparator

Control cells

Outcome

Interaction between JPs and DHPR, and functional effects on L-type Ca2+ current and DHPR localizationsurrogate

JP1 and JP2 interact with DHPRs and facilitate their assembly with other proteins of the excitation-contraction coupling machinery in skeletal muscle.

Cite This Study

Golini et al. (2011) studied this question.

synapsesocial.com/papers/6a829aa25b7acbbacb8d5eaf https://doi.org/10.1074/jbc.m111.292755

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Bookmark

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+ Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+ Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider