Population
Wild-type and JP-1-knockout (KO) mice (embryos and neonates)
Comparison
JP-1 knockout vs Wild-type mice
Design
Preclinical
Follow-up
Up to 1 day after birth
Authors
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JP-1 knockout causes neonatal lethality without triad increase in mice; leaves open its role in human skeletal or cardiac muscle disorders.
JP-1 is essential for the formation of triads in developing skeletal muscle, and its absence leads to neonatal lethality in mice.
Komazaki et al. (2002) studied this question.
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