Why the study?
Does nifedipine pretreatment reduce phasic contractions in isolated human epicardial coronary arteries?
Population
Human epicardial coronary artery rings freshly obtained from cardiac transplantation patients
Comparison
Nifedipine pretreatment prior to vasoconstrictor… vs Absence of nifedipine
Design
Preclinical
Authors
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Nifedipine abolishes phasic contractions in isolated arteries; leaves open whether L-type channel effects alter human coronary vasomotion in vivo.
Does nifedipine pretreatment reduce phasic contractions in isolated human epicardial coronary arteries?
Nifedipine abolishes phasic contractions in isolated human epicardial coronary arteries, revealing their underlying tonic vasoconstrictor profile and highlighting the role of dihydropyridine-sensitive calcium channels.
Stork et al. (1994) studied this question.
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