Why the study?
Does treatment with monoclonal antibodies to adhesion molecules reduce eosinophilic myocarditis and cardiac fibrosis in Toxocara canis-infected mice?
Population
CBA/J mice infected with Toxocara canis
Design
Preclinical
Follow-up
1 and 2 weeks after infection
Authors
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May guide adhesion molecule-targeted therapies in eosinophilic myocarditis; leaves open translation from murine models to patients.
Does treatment with monoclonal antibodies to adhesion molecules reduce eosinophilic myocarditis and cardiac fibrosis in Toxocara canis-infected mice?
Blockade of adhesion molecules significantly suppresses eosinophil infiltration and cardiac fibrosis in a murine model of eosinophilic myocarditis.
Hokibara et al. (1998) studied this question.
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