Key result
Adoptive transfer of splenocytes with ovalbumin challenge induces myocarditis in ~85% of recipient mice.
Population
Male DBA/2 mice (donor and recipient)
Comparison
Adoptive transfer of splenocytes from… vs Control mice
Design
Preclinical
Authors
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May advance understanding of eosinophilic myocarditis pathogenesis; leaves open translation to human disease.
Absolute Event Rate: 85% vs 0%
p-value: p=<0.05
A murine model of adoptive transferred myocarditis demonstrates that synergism between CD4 dominancy and JAK-STAT signaling may drive eosinophil recruitment into heart lesions.
Hirasawa et al. (2006) studied Eosinophilic myocarditis. Adoptive transfer of splenocytes with ovalbumin (OVA) challenge vs. Control mice was evaluated on Development of myocarditis (p=<0.05). Adoptive transfer of splenocytes with ovalbumin challenge induced myocarditis in approximately 85% of recipient mice, compared to none in controls.
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