Key result
CD8+ T cells primed in the presence of IL-12 caused lethal myocarditis in transgenic mice, whereas T cells primed without IL-12 failed to infiltrate the heart or cause disease.
IL-12 is essential for the differentiation of pathogenic CD8+ T cells capable of infiltrating the heart and causing autoimmune myocarditis.
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IL-12-dependent CD8+ T-cell pathogenicity in myocarditis is hypothesis-generating in mice; human relevance and therapeutic targeting remain unproven.
Grabie et al. (2003) studied Myocarditis. IL-12 primed OT-I CD8+ effector T cells vs. OT-I CD8+ effector T cells primed without IL-12 was evaluated on Lethal myocarditis / Survival. CD8+ T cells primed in the presence of IL-12 caused lethal myocarditis in transgenic mice, whereas T cells primed without IL-12 failed to infiltrate the heart or cause disease.
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