Population
Primary human umbilical vein endothelial cells and internal mammary arteries from patients undergoing…
Comparison
Angiotensin II stimulation and patient therapies vs Control conditions and control group
Design
Preclinical
Authors
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Statin and ACE-I therapy may upregulate arterial ECE-1 expression versus ARB; hypothesis-generating for vascular effects, needs clinical validation.
ECE-1a is the major ECE-1 isoform in primary human endothelial cells, and its expression in internal mammary arteries is modulated by statin and ACE-I/ARB therapies.
Göettsch et al. (2008) studied this question.
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