Population
Human and rat cells, including primary cultures of endothelial cells and smooth muscle cells
Comparison
Cloning and characterization of ECE-1d vs Other ECE-1 isoforms (ECE-1a, ECE-1b, ECE-1c)
Design
Preclinical
Authors
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Novel ECE-1d isoform exhibits functional equivalence and conservation; extends endothelin pathway characterization but leaves open physiologic roles in vivo.
The discovery of a fourth isoform of endothelin-converting enzyme (ECE-1d) expands the understanding of endothelin system regulation at the cellular level.
Valdenaire et al. (1999) studied this question.
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