June 1, 2006

Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain.

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Population

Endothelial cells derived from macrovascular and microvascular beds, and stably transfected human embryonic…

Comparison

Analysis of novel alternatively spliced… vs Full-length ECE-1 forms

Design

Preclinical

Authors

EKEyal KlipperGTx (United States)NLNitzan LevyBen-Gurion University of the Negev TGTamar GilboaHebrew University of Jerusalem

Discussion

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Implication

Indicates potential intracellular ECE-1 activity in animals; leaves open relevance to human cardiovascular disease.

Structured PICO

Population

Endothelial cells (EC) derived from macrovascular and microvascular beds, and stably transfected human embryonic kidney (HEK)-293 cells

Intervention

Analysis of novel alternatively spliced messenger RNAs (mRNAs) of ECE-1b, 1c, and 1d (ECE-1sv)

Comparator

Full-length ECE-1 forms

Outcome

Identification and characterization of ECE-1sv proteinsurrogate

The discovery of a novel cytosolic splice variant of ECE-1 lacking a transmembrane domain suggests distinct physiologic roles for ECE-1 isoforms in different cellular compartments.

Cite This Study

Klipper et al. (2006) studied this question.

synapsesocial.com/papers/6a89ced6b11dee029fbd5d29 https://doi.org/10.3181/00379727-231-2310723

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Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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