Population
Porcine cardiac muscle preparations and isolated human cardiac regulatory light chain (HCRLC) proteins
Comparison
Reconstitution with familial hypertrophic… vs Reconstitution with wild-type HCRLC and other…
Design
Preclinical
Authors
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May implicate regulatory light chain mutations in hypertrophic cardiomyopathy pathogenesis via altered calcium sensitivity; leaves open human translation.
Mutations in the Ca2+ binding site of the human cardiac regulatory light chain alter calcium sensitivity and force development, suggesting a mechanism for pathogenesis in familial hypertrophic cardiomyopathy.
Szczesna‐Cordary et al. (2004) studied this question.
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