Population
Human coronary arterioles (HCAs) and human coronary artery endothelial cells (HCAECs)
Comparison
Bradykinin stimulation, with or without NADPH… vs Control conditions
Design
Preclinical
Authors
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NADPH oxidase-derived H2O2 may modulate coronary tone; leaves open therapeutic targeting in human endothelial dysfunction.
Endothelial NADPH oxidase is a functionally relevant source of H2O2 that mediates bradykinin-induced vasodilation in human coronary arterioles.
Larsen et al. (2009) studied this question.
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