December 1, 2003AJP Heart and Circulatory Physiology

Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels

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Population

Pig subepicardial coronary arterioles (50-100 microm) isolated and pressurized without flow for in vitro study

Design

Preclinical

Authors

NTNaris ThengchaisriKasetsart University LKLih KuoTexas A&M Health Science Center

Discussion

Member takes

Implication

Preclinical findings only; leaves open H2O2's role in human coronary vasoregulation.

Structured PICO

Population

Pig subepicardial coronary arterioles (50-100 microm) isolated and pressurized without flow for in vitro study

Intervention

Abluminal hydrogen peroxide (H2O2) (1-100 microM) with or without various inhibitors (indomethacin, L-NAME, miconazole, AH-6809, KCl, iberiotoxin)

Outcome

Coronary arteriolar dilationsurrogate

H2O2 elicits coronary arteriolar dilation via both endothelium-dependent (COX-1/PGE2) and endothelium-independent (KCa channel hyperpolarization) mechanisms.

Cite This Study

Thengchaisri et al. (2003) studied this question.

synapsesocial.com/papers/6a6fffac6c240de38cdba5e8 https://doi.org/10.1152/ajpheart.00487.2003

View Full Paper

Ask AI

Bookmark

Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider