Population
Isolated porcine coronary arterioles
Comparison
Intraluminal incubation with H2O2 vs Control conditions (implied in vitro baseline)
Design
Preclinical
Authors
Loading...
H2O2 may impair coronary microvascular dilation via arginase in animals; leaves open whether arginase inhibition merits human study.
H2O2 impairs endothelium-dependent NO-mediated dilation in coronary microvessels by upregulating arginase and reducing L-arginine availability.
Thengchaisri et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: