Key result
Hydrogen peroxide impairs pulmonary artery endothelial cell barrier function without altering NOS activity.
Why the study?
The role of oxidant-mediated inhibition of nitric oxide synthase in hydrogen peroxide-induced endothelial injury was unclear.
Population
Porcine pulmonary artery endothelial cells
Comparison
Hydrogen peroxide exposure (10-250 microM) vs no exposure
Design
Preclinical experimental study
Follow-up
Up to 120 minutes
Authors
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Oxidant-induced pulmonary endothelial barrier dysfunction may be NO-independent; leaves open targeted therapies beyond the arginine-NO pathway.
Oxidant-induced vascular endothelial barrier dysfunction occurs independently of arginine-nitric oxide pathway disruption.
Gupta et al. (1998) studied Endothelial barrier dysfunction. Hydrogen peroxide (H2O2) was evaluated on PAEC barrier function and NOS activity. Hydrogen peroxide impaired porcine pulmonary artery endothelial cell barrier function without altering nitric oxide synthase activity or the arginine-nitric oxide pathway.
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