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January 1, 2001AJP Lung Cellular and Molecular Physiology

Nitric oxide attenuates H2O2-induced endothelial barrier dysfunction: mechanisms of protection

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Population

Cultured porcine pulmonary artery endothelial cell (PAEC) monolayers

Comparison

Nitric oxide generation vs H2O2 treatment alone or with inhibitors of…

Design

Preclinical

Authors

MGMahesh P. GuptaButler UniversityMOMichael D. OberIndiana University – Purdue University IndianapolisCPCarolyn E. PattersonGeorgia Institute of Technology

Discussion

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Implication

Supports PKA-dependent NO signaling for endothelial protection in oxidative injury; leaves open translation to human pulmonary disease.

Structured PICO

P
Population
Cultured porcine pulmonary artery endothelial cell (PAEC) monolayers
I
Intervention
Nitric oxide (.NO) generation (intracellular and extracellular)
C
Comparator
H2O2 treatment alone or with inhibitors of soluble guanylate cyclase, protein kinase G, or protein kinase A
O
Outcome
Endothelial barrier function measured as transmonolayer albumin clearancesurrogate

Nitric oxide protects against hydrogen peroxide-induced endothelial barrier dysfunction via cAMP-dependent, rather than cGMP-dependent, signaling mechanisms.

Cite This Study

Gupta et al. (2001) studied this question.

synapsesocial.com/papers/6a7e517216e5cfa85bb7b22ahttps://doi.org/10.1152/ajplung.2001.280.1.l116
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1H2O2causes endothelial barrier dysfunction without disrupting the arginine-nitric oxide pathway1998 · 20 citations
  2. 2Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability1996 · 134 citations
  3. 3cGMP and Nitric Oxide Modulate Thrombin-Induced Endothelial Permeability1995 · 199 citations
  4. 4Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade1993 · 173 citations
  5. 5Endothelium‐derived relaxing factor contributes to the regulation of endothelial permeability1992 · 83 citations