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August 31, 2016Frontiers in PhysiologyOpen Access

Commentary: Effect of Skeletal Muscle Native Tropomyosin on the Interaction of Amoeba Actin with Heavy Meromyosin

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Population

Amoeba actin, heavy meromyosin, and skeletal muscle native tropomyosin

Design

Editorial

Authors

JCJoseph M. ChalovichEast Carolina UniversityDJDylan JohnsonNational Institute of Environmental Health Sciences

Discussion

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Implication

Suggests myosin can overcome troponin inhibition at high Ca2+; leaves open relevance to cardiomyopathy mutations in patients.

Structured PICO

P
Population
Amoeba actin, heavy meromyosin, and skeletal muscle native tropomyosin
O
Outcome
Myosin ATPase activity and ATP hydrolysissurrogate

This commentary discusses the molecular mechanisms by which myosin S1 binding overcomes troponin inhibition to activate ATP hydrolysis in muscle contraction.

Cite This Study

Chalovich et al. (2016) studied this question.

synapsesocial.com/papers/6a76bf19d8eb58afc2bd6085https://doi.org/10.3389/fphys.2016.00377
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of the acto·myosin subfragment 1 interaction by troponin/tropomyosin. Evidence for control of a specific isomerization between two acto·myosin subfragment 1 states1991 · 59 citations
  2. 2The Δ14 Mutation of Human Cardiac Troponin T Enhances ATPase Activity and Alters the Cooperative Binding of S1-ADP to Regulated Actin2004 · 41 citations
  3. 3Ca2+S1-Induced Movement of Troponin T on Reconstituted Skeletal Muscle Thin Filaments Observed by Fluorescence Energy Transfer Spectroscopy2002 · 28 citations
  4. 4Manifestations of Cooperative Behavior in the Regulated Actin Filament during Actin-Activated ATP Hydrolysis in the Presence of Calcium1973 · 165 citations
  5. 5A model for the Ca2+-induced conformational transition of troponin C. A trigger for muscle contraction.1986 · 323 citations