Why the study?
Can high-sensitivity cardiac troponin T (hs-cTnT) measurement detect myocardial damage across different cardiac conditions compared to healthy controls?
Can high-sensitivity cardiac troponin T (hs-cTnT) measurement detect myocardial damage across different cardiac conditions compared to healthy controls?
High-sensitivity troponin T can detect minor myocardial damage in various cardiac conditions and differentiate between stable and unstable angina.
Cl sdlen: Monitorovat analytickou a klinickou vhodnost pouit nov high-senzitivn metody pro stanoven troponinu T (hs-cTnT).Metoda: Srov koncentrace troponinu T byla testovna high-senzitivn metodou pro analyztor Elecsys 2010 (Roche). Kardiln troponin T (cTnT) byl men v skupinch: 73 krevnch drc (BD), 41 akutnch infarkt myokardu (AIM), 34 nestabilnch angin pectoris (UAP), 38 stabilnch angin pectoris (SAP), 22 hypertrofickch kardiomyopati (HKM) a 27 rznch typ arytmi (AR).Vsledky: Koncentrace hs-cTnT byla zven nad 99. percentil kontroln populace (BD) u 100 % AIM, 63,6 % UAP, 15,8 % SAP, 18,5 % AR a13,6 % HKM.Zvry: High-senzitivn metoda m adekvtn analytick vlastnosti. Nae data ukazuj, e zven hs-cTnT me monitorovat mal pokozen myokardu u pacient s AKS nebo s jinou chronickou srden chorobou. Byly nalezeny signifikantn rozdly ve vsledcch mezi BD, SAP a UAP skupinami, co me bt vyuito pro stratifikaci rizika. Vsledky nzkch koncentrac cTnT (< 0,03μg/l) mohou bt uiten pro klinickou interpretaci, ale je teba pesn stanovit referenn limity.
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Vašatová et al. (2010) studied this question.
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