SINCE the initial report that LHRH-expressing neurons migrate during development from their birth place on the medial side of the olfactory placode into the brain (1), two sorts of questions have received additional experimentation and discussion. First, what light does this unusual migration into the developing brain shed on the nature of LHRH-expressing cells, and what are the implications for their normal roles in the adult brain? Second, what would be the implications of migration disturbances for human reproductive physiology, including Kallmann's and other syndromes (see companion paper by Dr. Crowley)? Accordingly, the purposes of this review are to reexamine some of the evidence concerning normal controls over LHRH neurons in light of what these cells are supposed to do in the adult brain; to review the burgeoning evidence that they actually originate in the olfactory pit and migrate into the developing forebrain; and to introduce the subject of Kallmann's syndrome (see companion paper by Dr. Crowley).
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Schwanzel‐Fukuda et al. (1992) studied this question.