Why the study?
Does prophylactic bretylium prevent arrhythmias, myocardial necrosis, shock, congestive heart failure, and mortality in patients with acute myocardial infarction?
Does prophylactic bretylium prevent arrhythmias, myocardial necrosis, shock, congestive heart failure, and mortality in patients with acute myocardial infarction?
Prophylactic bretylium may prevent arrhythmias, myocardial necrosis, heart failure, and mortality in AMI patients by blocking deleterious adrenergic hyperactivity.
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Hypothesis-generating for adrenergic blockade in AMI; leaves open confirmation in contemporary randomized trials.
Bacaner et al. (2004) studied this question.
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