Why the study?
Does altering O2 delivery rate affect isometric tension development in isolated blood-perfused dog hearts?
Population
Isolated blood-perfused heart of dogs
Comparison
Altering O2 delivery rates by changing coronary… vs Various levels of O2 delivery rates and resting…
Design
Preclinical
Authors
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O2 delivery may determine tension capacity in isolated hearts; leaves open translation to in vivo human Frank-Starling physiology.
Does altering O2 delivery rate affect isometric tension development in isolated blood-perfused dog hearts?
The metabolic state of the myocardium, determined by O2 delivery rate, is a major determinant of tension-producing capacity and the magnitude of adaptation via the Frank-Starling mechanism.
Bacaner et al. (1971) studied this question.
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