Why the study?
Does varying oxygen content in hemoglobin solutions affect coronary flow, heart rate, myocardial oxygen consumption, and tension in isolated rabbit hearts?
Population
Isolated rabbit heart perfused with hemoglobin solutions
Comparison
Perfusion with hemoglobin solutions of varying… vs Different levels of oxygen content
Design
Preclinical
Authors
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Indicates oxygen-dependent coronary flow regulation in isolated hearts; leaves open translation to in vivo human physiology.
Does varying oxygen content in hemoglobin solutions affect coronary flow, heart rate, myocardial oxygen consumption, and tension in isolated rabbit hearts?
In isolated rabbit hearts, decreasing oxygen content in the perfusate increases coronary flow while maintaining constant heart rate, myocardial tension, and oxygen consumption above 2 vol. % oxygen capacity.
Guz et al. (1960) studied this question.
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