Key result
In anaesthetised-chest rabbits, a significant inverse linear relationship was found between the coefficient of variation of myocardial blood flow and mean flow over the entire range studied (r = -0.482).
Effect estimate: r = -0.482
Decreased spatial heterogeneity of myocardial blood flow accompanies high flows or reduced vascular resistance, which may be beneficial for O2 supply and demand during myocardial stress.
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May inform myocardial O2 supply-demand matching at high flows in rabbits; leaves open human translation.
Conway et al. (1985) studied Myocardial blood flow spatial heterogeneity. Treatments to alter coronary flow (hypoxia, hyperoxia, hypercapnia, adenosine, chromomar HCl) was evaluated on Relationship between spatial heterogeneity (coefficient of variation) and mean coronary flow (r = -0.482). In anaesthetised-chest rabbits, a significant inverse linear relationship was found between the coefficient of variation of myocardial blood flow and mean flow over the entire range studied (r = -0.482).
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