Population
12 dogs (508 individual 0.5-g samples from the left ventricular free wall)
Design
Preclinical
Authors
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Metabolite concentrations explain minimal myocardial blood flow heterogeneity in this animal model; hypothesis-generating for dominant local regulators.
Although there is a physiological link between local blood flow and metabolite content in the heart, true local variability of blood flow is likely modulated predominantly by other factors.
Franzen et al. (1988) studied this question.