Key result
In anesthetized rabbits, hypoxia decreased myocardial blood flow heterogeneity and increased the similarity of blood flows in nearby regions compared to normoxia (P<0.001).
Why the study?
Does a hypoxic state alter the microheterogeneity of myocardial blood flow in anesthetized rabbits compared to a normoxic state?
Population
Anesthetized rabbits
Comparison
Hypoxic state (PaO2 = 26 +/- 5 mmHg) vs Normoxic state (PaO2 = 97 +/- 20 mmHg)
Design
Preclinical
Authors
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Hypoxia effects on rabbit myocardial perfusion are hypothesis-generating; human studies needed before clinical relevance.
Does a hypoxic state alter the microheterogeneity of myocardial blood flow in anesthetized rabbits compared to a normoxic state?
p-value: p=<0.001
In a rabbit model, hypoxia decreases myocardial blood flow heterogeneity and increases the similarity of regional blood flows.
Matsumoto et al. (1996) studied Myocardial blood flow (animal model). Hypoxic state vs. Normoxic state was evaluated on Coefficient of variation (CV) and correlation between adjacent regional flows (CA) of myocardial blood flow (p=<0.001). In anesthetized rabbits, hypoxia decreased myocardial blood flow heterogeneity and increased the similarity of blood flows in nearby regions compared to normoxia (P<0.001).