December 1, 1989The Journal of PhysiologyOpen Access

Dynamic response of the coronary circulation to a rapid change in its perfusion in the anaesthetized goat.

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Population

Anaesthetized goat model (cannulated main stem preparation)

Comparison

Sudden change in perfusion pressure or sudden… vs Different directions of change

Design

Preclinical

Authors

JDJenny DankelmanDelft University of Technology JSJos A. E. SpaanLeiden University CPC. P. Van der PloegMedical University of Ilam

Discussion

Member takes

Implication

These animal kinetics should not inform clinical decisions; leaves open arteriolar mechanics beyond oxygen demand in coronary regulation.

Structured PICO

Population

Anaesthetized goat model (cannulated main stem preparation)

Intervention

Sudden change in perfusion pressure (constant-pressure perfusion) or sudden change in flow (constant-flow perfusion)

Comparator

Different directions of change (increase vs decrease)

Outcome

Rate of change of the pressure-flow ratio (quantified by t50, the time required to establish half of the completed response)surrogate

The rate of coronary adjustment to mechanical step changes differs depending on the direction of change, suggesting a role for arteriolar smooth muscle mechanics not fully predicted by the oxygen hypothesis.

Cite This Study

Dankelman et al. (1989) studied this question.

synapsesocial.com/papers/6a8986b641f4089922bd641e https://doi.org/10.1113/jphysiol.1989.sp017894

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Dynamic response of the coronary circulation to a rapid change in its perfusion in the anaesthetized goat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dynamic response of the coronary circulation to a rapid change in its perfusion in the anaesthetized goat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider