Key result
Fentanyl/pancuronium anesthesia significantly slowed the rate of coronary flow adaptation to heart rate changes compared to the awake state (t50 10.2s vs 5.0s for HR step-up).
Why the study?
Does fentanyl/pancuronium anesthesia alter the rate of coronary flow adaptation in response to changes in heart rate in patients with stable coronary artery disease?
Population
11 patients with stable coronary artery disease undergoing coronary artery surgery
Comparison
Fentanyl and pancuronium bromide anesthesia in… vs Awake state (before induction of anesthesia)
Design
Other
Authors
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May warrant anesthesia caution during HR fluctuations in stable CAD; leaves open clinical relevance pending prospective trials.
Observational (n=11)
Does fentanyl/pancuronium anesthesia alter the rate of coronary flow adaptation in response to changes in heart rate in patients with stable coronary artery disease?
Absolute Event Rate: 10.2% vs 5%
Fentanyl/pancuronium anesthesia significantly slows the rate of coronary flow adaptation in response to heart rate changes in patients with coronary artery disease.
Wezel et al. (1996) conducted an observational in Stable coronary artery disease (n=11). Fentanyl/pancuronium anesthesia vs. Awake state was evaluated on Rate of change of coronary resistance index (t50) after a heart rate step-up. Fentanyl/pancuronium anesthesia significantly slowed the rate of coronary flow adaptation to heart rate changes compared to the awake state (t50 10.2s vs 5.0s for HR step-up).
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