What question did this study set out to answer?

To examine how alterations in coronary blood flow affect myocardial oxygen consumption and mechanical performance under varying cardiac workloads.

September 1, 1965American Journal of Physiology-Legacy Content

Induced change in heart metabolism as a primary determinant of heart performance

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Why the study?

Does coronary blood flow rate determine cardiac work capacity and performance in isolated dog hearts?

Population

65 isolated dog hearts

Comparison

Imposed changes in coronary blood flow and heart… vs Various levels of coronary blood flow and heart…

Design

Preclinical

Authors

MBMarvin BacanerUniversity of Minnesota FLFranco LioyUniversity of Minnesota MVMaurice B. VisscherUniversity of Southern California

Discussion

Member takes

Implication

Coronary flow may modulate LV performance in isolated hearts; leaves open translation to human disease.

Key Points

To examine how alterations in coronary blood flow affect myocardial oxygen consumption and mechanical performance under varying cardiac workloads.
Measured left ventricular isometric developed tension (LVDT) and isotonic shortening (LVS) across various coronary blood flow (CBF) levels and loading states in isolated dog hearts (N=65).
Assessed coronary blood flow autoregulation during variations in arterial oxygen saturation.
Imposed alterations in CBF caused directionally matching changes in both contractile indices (LVDT and LVS) and myocardial oxygen consumption across heart workloads.
CBF magnitude governed the extent of ventricular contractile responsiveness to altered preload and afterload (Starling effect).
CBF autoregulation occurred in select hearts, was abolished by lowering arterial oxygen saturation, and was fully restored upon arterial resaturation.

Structured PICO

Does coronary blood flow rate determine cardiac work capacity and performance in isolated dog hearts?

Population

65 isolated dog hearts

Intervention

Imposed changes in coronary blood flow (CBF) and heart load

Comparator

Various levels of coronary blood flow and heart load

Outcome

Left ventricular isometric developed tension (LVDT) or isotonic shortening (LVS) and O2 consumptionsurrogate

Coronary blood flow rate is a primary determinant of cardiac work capacity and performance by regulating oxygen and substrate delivery.

Cite This Study

Bacaner et al. (1965) studied this question.

synapsesocial.com/papers/6a75cdabf718b06d6813cc69 https://doi.org/10.1152/ajplegacy.1965.209.3.519

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Induced change in heart metabolism as a primary determinant of heart performance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Induced change in heart metabolism as a primary determinant of heart performance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider