August 1, 1991Journal of Neurochemistry

Solubilization and Partial Characterization of Angiotensin II Receptors from Rat Brain

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Population

Rat brain membranes

Comparison

Solubilization using the synthetic detergent… vs Intact brain membranes

Design

Preclinical

Authors

ISIvo R. SiemensNew Frontier GSGeoffrey N. SwansonWashington State University SFSteven J. FluhartyUniversity of Pennsylvania

Discussion

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Implication

Enables further molecular characterization of rodent brain Ang II receptors; leaves open translation to human cardiovascular disease.

Structured PICO

Population

Rat brain membranes

Intervention

Solubilization using the synthetic detergent 3[(3-cholamidopropyl)dimethylammonio)]-1-propanesulfonate

Comparator

Intact brain membranes

Outcome

Properties of solubilized Angiotensin II receptors (kinetic analysis, molecular weights, isoelectric point)surrogate

Successful solubilization of Angiotensin II receptors from rat brain membranes preserves their binding properties, facilitating further molecular characterization.

Cite This Study

Siemens et al. (1991) studied this question.

synapsesocial.com/papers/6a76cbc9a0847c3df1ec3622 https://doi.org/10.1111/j.1471-4159.1991.tb03801.x

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Solubilization and Partial Characterization of Angiotensin II Receptors from Rat Brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Solubilization and Partial Characterization of Angiotensin II Receptors from Rat Brain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider