Aggressive Blood Pressure Control Increases Coronary Heart Disease Risk Among Diabetic Patients
Why the study?
Does aggressive blood pressure control increase the risk of incident coronary heart disease in diabetic patients?
Population
30,154 diabetic patients, including 17,536 African Americans and 12,618 whites
Comparison
Aggressive blood pressure control and various… vs Blood pressure 130-139/80-90 mmHg
Design
Cohort
Follow-up
mean 6.0 years
Authors
Discussion
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Member takes
Implication
May warrant caution with BP <110/65 mmHg in diabetes; leaves open optimal targets pending RCTs.
Structured PICO
Does aggressive blood pressure control increase the risk of incident coronary heart disease in diabetic patients?
P
Population
30,154 diabetic patients, including 17,536 African Americans and 12,618 whites
I
Intervention
Aggressive blood pressure control (blood pressure <120/70 mmHg) and various blood pressure strata (<110/65, 110-119/65-69, 120-129/70-80, 140-159/90-100, and ≥160/100 mmHg)
C
Comparator
Blood pressure 130-139/80-90 mmHg (reference group)
O
Outcome
Incident coronary heart disease (CHD)hard clinical
In diabetic patients, there is a U-shaped association between blood pressure and CHD risk, suggesting that aggressive blood pressure control (<120/70 mmHg) may paradoxically increase the risk of incident coronary heart disease.
Cite This Study
Zhao et al. (2013) studied this question.