Key result
In patients with type 2 diabetes, each 10-mmHg increase in systolic blood pressure was associated with increased risks of CHD (HR 1.08; 95% CI 1.04-1.13) and stroke (HR 1.20; 95% CI 1.13-1.27).
Why the study?
Does higher systolic blood pressure increase the risk of fatal/nonfatal CHD, stroke, and CVD in patients with type 2 diabetes on antihypertensive therapy?
Population
12,677 patients aged 30-75 years with type 2 diabetes, treated with antihypertensive drugs, without previous…
Comparison
Higher systolic blood pressure levels vs Lower SBP levels (e.g., 110-129 mmHg as reference)
Design
Cohort
Follow-up
5 years
Authors
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Supports linear SBP-CVD risk in treated T2D without J-curve; leaves open optimal targets for RCTs.
Observational (n=12,677)
Yes
Does higher systolic blood pressure increase the risk of fatal/nonfatal CHD, stroke, and CVD in patients with type 2 diabetes on antihypertensive therapy?
Hazard Ratio: 1.08 (95% CI 1.04–1.13)
p-value: p=<0.001
In patients with type 2 diabetes on antihypertensive therapy, SBP ≥140 mmHg is associated with significantly increased risks of CHD, stroke, and CVD compared to 110-129 mmHg, with no J-shaped curve observed.
Cederholm et al. (2010) conducted an observational in type 2 diabetes (n=12,677). Systolic blood pressure vs. Lower systolic blood pressure levels was evaluated on fatal/nonfatal coronary heart disease (CHD) (HR 1.08, 95% CI 1.04-1.13, p=<0.001). In patients with type 2 diabetes, each 10-mmHg increase in systolic blood pressure was associated with increased risks of CHD (HR 1.08; 95% CI 1.04-1.13) and stroke (HR 1.20; 95% CI 1.13-1.27).
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