Why the study?
Does CV-11974 improve myocardial metabolism and relaxation during ischemia and reperfusion in Langendorff-perfused rabbit hearts?
Population
Langendorff-perfused rabbit hearts (n=28)
Comparison
CV-11974 (10 mol/L) administered 40 min prior to… vs Control group (no CV-11974)
Design
Preclinical
Follow-up
20 min ischemia and 30 min reperfusion
Authors
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Supports AT1 antagonism for ischemic myocardial preservation; hypothesis-generating in rabbit models and leaves open human translation.
Does CV-11974 improve myocardial metabolism and relaxation during ischemia and reperfusion in Langendorff-perfused rabbit hearts?
The AT1 receptor antagonist CV-11974 improves myocardial energy metabolism and relaxation during ischemia and reperfusion via K(ATP) channels mediated by the bradykinin B2 receptor in a rabbit heart model.
Kawabata et al. (2001) studied this question.
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