Why the study?
Does the combination of TAK-044 and temocaprilat improve myocardial metabolism and contraction during ischemia and reperfusion in isolated rabbit hearts?
Population
28 isolated Langendorff-perfused hearts from male Japanese white rabbits weighing 1.6-1.7 kg.
Comparison
TAK-044 and/or temocaprilat administered from 40… vs Control group with no administration of either…
Design
Preclinical
Follow-up
60 minutes of postischemic reperfusion
Authors
Loading...
Hypothesis-generating for dual endothelin-ACE inhibition in myocardial protection; leaves open translation to function or clinical settings.
Does the combination of TAK-044 and temocaprilat improve myocardial metabolism and contraction during ischemia and reperfusion in isolated rabbit hearts?
The combination of an endothelin receptor antagonist and an ACE inhibitor synergistically improves myocardial energy metabolism during ischemia and reperfusion in an isolated rabbit heart model, though without immediate improvement in contractility.
Kawabata et al. (1999) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: