Key result
Pravastatin improves ischemic myocardial energy metabolism in rabbit hearts without added ACEi or ARB benefit.
Why the study?
The effects of pravastatin alone or combined with ACE inhibitor or AT1 receptor antagonist on myocardial metabolism during ischemia were unclear.
Does pravastatin alone or in combination with ACE inhibitors or AT1 receptor antagonists improve myocardial energy metabolism during ischemia in isolated rabbit hearts?
Comparison
Pravastatin alone, pravastatin plus temocaprilat, pravastatin plus CV-11974, pravastatin plus L-NAME, and control
Design
Preclinical experimental study with multiple treatment groups
Authors
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Pravastatin may preserve ischemic myocardial energetics via NOS; leaves open translation to humans or additive effects with ACEI/ARB.
Does pravastatin alone or in combination with ACE inhibitors or AT1 receptor antagonists improve myocardial energy metabolism during ischemia in isolated rabbit hearts?
Absolute Event Rate: 64% vs 42%
p-value: p=<0.01
Pravastatin improves myocardial energy metabolism during ischemia via a nitric oxide synthase-dependent mechanism, without additive benefits from ACE inhibition or AT1 receptor antagonism.
Kawabata et al. (2002) studied Myocardial ischemia (n=49). Pravastatin alone or in combination with temocaprilat or CV-11974 vs. Vehicle (physiologic saline) was evaluated on Myocardial energy metabolism (ATP, Pi, pHi) at 42.5 minutes of ischemia (p=<0.01). Pravastatin significantly improved myocardial energy metabolism during ischemia in isolated rabbit hearts, but this beneficial effect was not enhanced by the addition of an ACE inhibitor or AT1 receptor antagonist.
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