January 1, 2007Circulation JournalOpen Access

Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits

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Why the study?

Does pravastatin reduce myocardial infarct size in rabbits undergoing ischemia and reperfusion?

Population

Rabbits undergoing 30 min of coronary occlusion followed by 48 h of reperfusion

Comparison

Pravastatin administered intravenously 10 min… vs Saline (control)

Design

Preclinical

Follow-up

48 hours of reperfusion

Authors

NBNarentuoya BaoGifu University SMShinya MinatoguchiHeart Failure / Cardiomyopathy HKHiroyuki KobayashiUniversity of Tsukuba

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for pravastatin preconditioning in myocardial ischemia-reperfusion.

Structured PICO

Does pravastatin reduce myocardial infarct size in rabbits undergoing ischemia and reperfusion?

Population

Rabbits undergoing 30 min of coronary occlusion followed by 48 h of reperfusion

Intervention

Pravastatin (1 or 5 mg/kg) administered intravenously 10 min before ischemia, or pravastatin (5 mg/kg) administered 10 min before reperfusion. Additional groups received L-NAME, chelerythrine, or 5-HD before pravastatin.

Comparator

Saline (control)

Outcome

Myocardial infarct sizesurrogate

Pre-ischemic administration of pravastatin reduces myocardial infarct size in a rabbit model via PKC-dependent nitric oxide production, reduction of oxyradicals, and opening of mitochondrial ATP-sensitive potassium channels.

Cite This Study

Bao et al. (2007) studied this question.

synapsesocial.com/papers/6a90e83c152a692a9d92d581 https://doi.org/10.1253/circj.71.1622

Topics

Statin therapy

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Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider