Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.
Population
Isolated preparations from nonfailing donor hearts and moderately to severely failing human myocardium
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Pimobendan effects in failing human myocardium merit clinical investigation; leaves open translation to patient outcomes in prospective trials.
Structured PICO
P
Population
Isolated preparations from nonfailing donor hearts and moderately (NYHA II-III) to severely (NYHA IV) failing human myocardium
I
Intervention
Pimobendan and its demethylated metabolite UD-CG 212 Cl
O
Outcome
Positive inotropic effect, cAMP-PDE inhibition, and Ca2+ sensitivity of myofilamentssurrogate
Pimobendan exerts a positive inotropic effect in failing human myocardium through a dual mechanism involving PDE III inhibition and sensitization of contractile proteins to calcium.
Cite This Study
Böhm et al. (1991) studied this question.