Population
Skinned and intact ventricular muscle from ferrets
Comparison
Pimobendan (20, 25, or 100 mumol/l) vs Changes in extracellular [Ca2+] and isoprenaline
Design
Preclinical
Authors
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Clarifies pimobendan’s dual mechanism in animals; hypothesis-generating for clinical heart failure use pending human trials.
Pimobendan exerts its positive inotropic effects through a dual mechanism of increasing myofibrillar calcium sensitivity and inhibiting phosphodiesterase.
Lee et al. (1989) studied this question.
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