April 1, 1989The Journal of Clinical Pharmacology

Pimobendan Increases Calcium Sensitivity of Skinned Human Papillary Muscle Fibers

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Why the study?

Does pimobendan increase calcium sensitivity and force production in skinned human papillary muscle fibers?

Population

Chemically skinned human papillary muscle fibers obtained from patients undergoing mitral valve replacement…

Comparison

Pimobendan (10-300 mumol/l) vs Baseline/control without pimobendan

Design

Preclinical

Authors

HSHans H. ScheldHeart Failure / Cardiomyopathy RFRaphael FritscheUniversity of Lucerne MSM. SchlepperMax Planck Institute for Heart and Lung Research

Discussion

Member takes

Implication

Hypothesis-generating for pimobendan in failing myocardium; leaves open whether calcium sensitization improves clinical outcomes.

Structured PICO

Does pimobendan increase calcium sensitivity and force production in skinned human papillary muscle fibers?

Population

Chemically skinned human papillary muscle fibers obtained from patients undergoing mitral valve replacement operations (including patients with normal and reduced left ventricular performance, NYHA II and III).

Intervention

Pimobendan (10-300 mumol/l)

Comparator

Baseline/control without pimobendan

Outcome

Force production (pCa-tension relationship)surrogate

Pimobendan increases calcium sensitivity in human papillary muscle fibers, with a more pronounced effect in failing myocardium.

Cite This Study

Scheld et al. (1989) studied this question.

synapsesocial.com/papers/6a8196b521d82b3fa6775e80 https://doi.org/10.1002/j.1552-4604.1989.tb03342.x

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Pimobendan Increases Calcium Sensitivity of Skinned Human Papillary Muscle Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pimobendan Increases Calcium Sensitivity of Skinned Human Papillary Muscle Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider