Global stability and uniform persistence in an epidemic model with saturating fomite-mediated transmission

We analyse the global dynamics of a Susceptible–Vaccinated–Exposed–Infected–Recovered (SVEIR) epidemic model with demographic turnover, imperfect vaccination, and two transmission routes: direct host-to-host contagion and indirect transmission via contaminated fomites. Indirect transmission is described through an environmental pathogen concentration and a Holling-type dose–response function, accounting for nonlinear incidence at high contamination levels. Threshold conditions separating disease elimination from long-term persistence are expressed in terms of the control reproduction number Rc R c , and the classical threshold condition Rc<1 R c < 1 is derived for the local asymptotic stability of the disease-free equilibrium. For the Holling type II case, we further obtain an explicit closed-form sufficient condition for the global asymptotic stability of the disease-free equilibrium by applying the Kamgang–Sallet approach for monotone systems with a Metzler infected subsystem. In the absence of vaccination, this criterion recovers the sharp threshold R₀≤ 1 R 0 ≤ 1 for the global asymptotic stability of the disease-free equilibrium, where R₀ R 0 denotes the basic reproduction number. Conversely, when Rc>1 R c > 1 , we establish uniform persistence of the infection and the existence of at least one endemic equilibrium using persistence theory for semiflows and an acyclicity analysis of the boundary dynamics. Overall, our results quantify the combined impact of vaccination and saturating fomite-mediated transmission on the global behaviour of the model.