Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium
Population
Human ventricular myocardium
Comparison
Bucindolol, carvedilol, and metoprolol vs Compared to each other
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May underlie beta-blocker tolerability differences in HF; animal data leave open clinical translation.
Structured PICO
P
Population
Human ventricular myocardium (membrane preparations of failing and nonfailing myocardium, and isolated muscle preparations of left ventricular myocardium from failing hearts)
I
Intervention
Bucindolol, carvedilol, and metoprolol
C
Comparator
Compared to each other
O
Outcome
Beta-adrenoceptor-G-protein coupling and intrinsic activity (force of contraction)surrogate
In human ventricular myocardium, bucindolol displays substantially higher intrinsic activity than metoprolol and carvedilol, which may explain differences in beta-blocker tolerability and outcomes in heart failure.
Cite This Study
Maack et al. (2000) studied this question.