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June 15, 2004Journal of Hypertension

Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension

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Why the study?

Do polymorphic variants in the NHE3 gene associate with essential hypertension and sodium balance indices in black and white populations?

Population

691 subjects, including 399 of African or Afro-Caribbean origin and 292 of Caucasian origin.

Comparison

Presence of A2041G and C2405T polymorphisms in… vs Absence of these polymorphisms or alternative…

Design

Case-control

Authors

HZHaidong ZhuAugusta UniversityGSGiuseppe A. SagnellaUniversity of LondonYDYanbin DongChinese Academy of Sciences

Discussion

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Implication

These NHE3 variants lack association with hypertension or sodium indices; leaves open roles for other polymorphisms or interactions in larger cohorts.

Structured PICO

Do polymorphic variants in the NHE3 gene associate with essential hypertension and sodium balance indices in black and white populations?

P
Population
691 subjects, including 399 of African or Afro-Caribbean origin (68% with essential hypertension) and 292 of Caucasian origin (50% with essential hypertension).
I
Intervention
Presence of A2041G and C2405T polymorphisms in the sodium/hydrogen exchanger type 3 (NHE3) gene
C
Comparator
Absence of these polymorphisms or alternative genotypes
O
Outcome
Essential hypertension and biochemical indices of sodium balance (serum electrolytes, creatinine, plasma renin activity)

The A2041G and C2405T polymorphisms in the C terminus of the NHE3 gene are not significantly associated with essential hypertension or sodium balance in black or white populations.

Limitations

  • Cannot exclude the existence of functionally important genetic variants in other sequences within the NHE3 gene

Cite This Study

Zhu et al. (2004) studied this question.

synapsesocial.com/papers/6a76de6c4fe2e6ffd8ec3c6dhttps://doi.org/10.1097/01.hjh.0000125428.28861.11

Topics

Hypertension management
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Also Consider

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  1. 1A population study of ethnic variations in the angiotensin-converting enzyme I/D polymorphism1999 · 113 citations
  2. 2Plasma atrial natriuretic peptide: Its relationship to changes in sodium intake, plasma renin activity and aldosterone in man1987 · 42 citations
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  4. 4NHERF: targeting and trafficking membrane proteins2001 · 180 citations
  5. 5Genetic Analysis of the β Subunit of the Epithelial Na + Channel in Essential Hypertension1998 · 122 citations