Why the study?
Does corticosteroid therapy prevent angina attacks in a patient with refractory multivessel vasospastic coronary angina and hypereosinophilia?
Does corticosteroid therapy prevent angina attacks in a patient with refractory multivessel vasospastic coronary angina and hypereosinophilia?
Corticosteroid therapy successfully controlled refractory multivessel vasospastic angina associated with hypereosinophilia.
Hypereosinophilia may underlie refractory multivessel vasospasm; leaves open whether eosinophil-targeted therapy improves control.
A 43-year-old man was diagnosed with acute myocardial infarction (AMI) due to multivessel coronary vasospasm. Accordingly, two coronary vasodilators were administered, and he was discharged without an angina attack. However, from the following day, he reported frequent chest pain and was re-hospitalized. Despite adding multiple coronary vasodilators, it was difficult to completely suppress the angina attack. He also demonstrated hypereosinophilia from the onset of AMI, and his eosinophil count gradually increased up to 6,238/μL. After corticosteroid administration was started, the vasospasm was completely controlled, and his eosinophil count normalized. He remained free from angina attacks for two years with corticosteroid therapy.
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Takano et al. (2018) studied this question.
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